Cite this as
Heidari A (2017) Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation. Open J Anal Bioanal Chem 1(1): 021-026. DOI: 10.17352/ojabc.000004Vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hyroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) are member of organic compounds and an essential nutrients that an organism requires in limited amounts which plays a vital role in reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of malignant prostate tumors into benign prostate tumors under synchrotron radiation [1–44]. In addition, vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones), with a Cobalt (III) core, serves as catalysts for Triptorelin (Figure 1) as a Decapeptide (pGlu–His–Trp–Ser–Tyr–D–Trp–Leu–Arg–Pro–Gly–NH2) which is a Gonadotropin–Releasing Hormone agonist (GnRH agonist) used as the Acetate or Pamoate Salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) [45–99]. On the other hand, mesoporous nanomaterials are ideal supports for immobilization and extraction of these large biomolecules. It should be noted that SBA–1, SBA–3, SBA–15 and MCM–41 mesoporous silica are synthesized by Cetrimonium Bromide [(C16H33)N(CH3)3]Br; cetyltrimethylammonium bromide; hexadecyltrimethylammonium bromide; CTAB] quaternary ammonium surfactant via liquid phase deposition procedure. The synthesized mesoporous silica are characterized by Energy Dispersive X–Ray Analysis (EDXA), Energy Dispersive X–Ray Microanalysis (EDXMA), Scanning Electron Microscope (SEM), X–Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA), Energy–Dispersive X–Ray Spectroscopy (EDX), 1HNMR, 13CNMR, UV–Vis, HR–Mass, Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR–FTIR) and FT–Raman spectroscopies. Then, immobilization of vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) within the mesoporous silica are studied for the first time.
Characterization of vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) containing mesoporous support are described using Energy Dispersive X–Ray Analysis (EDXA), Energy Dispersive X–Ray Microanalysis (EDXMA), Scanning Electron Microscope (SEM), X–Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Differential Thermal Analysis–Thermal Gravim Analysis (DTA–TGA), Energy–Dispersive X–Ray Spectroscopy (EDX), 1HNMR, 13CNMR, UV–Vis, HR–Mass, Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR–FTIR) and FT–Raman spectroscopies. Effect of mesoporous pore size on immobilization of these relatively large biomolecules is taken into consideration. Results show that pore size plays a vital role on immobilization of large biomolecules. The newly synthesized mesostructured hybrid catalysts are investigated for reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of malignant prostate tumors into benign prostate tumors under synchrotron radiation. The ultrahigh specific area and highly dispersed catalysts species in SBA–1, SBA–3, SBA–15 and MCM–41/vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) nanomaterials create effective and active heterogeneous catalysts for oxidation purposes in presence of Hydrogen Peroxide as oxidant with high conversion 84%. Vacant SBA–1, SBA–3, SBA–15 and MCM–41 mesoporous silica are also studied for catalytic purposes. Results reveal that immobilized vitamins A (Retinol, retinal, and four carotenoids including beta carotene), B1 (Thiamine), B2 (Riboflavin), B3 (Niacin, niacinamide, Nicotinamide riboside), B5 (Pantothenic acid), B6 (Pyridoxine, pyridoxamine, pyridoxal), B7 (Biotin), B9 (Folates), B12 (Cyanocobalamin, hydroxocobalamin, methylcobalamin, adenosylcobalamin), C (Ascorbic acid), D2 (Ergocalciferol), D3 (Cholecalciferol), E (Tocopherols, tocotrienols) and K (Phylloquinone, menaquinones) biomolecules are the effective catalytic species responsible for reducing negative effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on prostate cancer cells and tissues in prostate cancer treatment process through transformation of malignant prostate tumors into benign prostate tumors under synchrotron radiation.
Subscribe to our articles alerts and stay tuned.
PTZ: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.
If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."