Serum Albumin as a Probable Extracellular Chaperone

Sadaf Khan* and Aabgeena Naeem

Serum albumin has been known for its function as a carrier protein. Recently there have been several studies that reflect the potential role of serum albumin as an extracellular chaperone. Depletion of serum albumin from the plasma has been linked to impaired cognitive function and the potential risk of developing neurodegenerative diseases. Being irreversible in nature, neurodegenerative diseases pose a serious health risk to society. Analyzing the nature of the insult and deficiency in extracellular proteostasis that could predispose the extracellular environment to these misfolding and aggregation-related disorders is very significant. Being a major protein in the plasma, serum albumin holds great potential to serve as an extracellular chaperone.

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Published on: Nov 23, 2024 Pages: 6-9

Full Text PDF Full Text HTML DOI: 10.17352/ab.000009
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