Research Interest: Asymmetric synthesis, total synthesis of natural products, multi-component reactions, heterocyclic synthesis and green chemistry

Research Interest: Pharmaceutical analytical chemistry, chemometrics, HPLC, HPTLC, GFAAS, spectrophotometry, analysis of drugs in pharmaceuticals and in biological fluids

Research Interest: Photocatalysis, colloid and interfacial phenomenon, CO2 capture and storage, multiphase flow in porous materials,

Grants:
 i) 5.2018-5.2020, UGC-UKIERI, £50000, Novel EOR technique for the depleted oil reservoirs of Upper Assam Basin with simultaneous CO2 Capture and Sequestration. (PI)
(ii) 10.2017-9.2018, EPSRC, £10000, EPSRC Formulations for collaboration with the University of Nottingham
(iii) 8.2016 - 7.2019, EPSRC, EP/N024672/1, £1,226,534, A compact CO2 capture process to combat industrial emissions.
(iv) 2013 - 9. 2015 Royal Society of Edinburgh, Removal of SOx and NOx from fossil fuel combustion, £11,600.
(v) 1.2013 - 4.2016, EPSRC, EP/J019720/1, £832,807, Feasibility of a wetting layer absorption carbon capture process based on chemical solvents. For this project, I supervised a research associate working on microwave swing adsorption for CO2 capture.
(vi) 2012-2013, Royal Academy of Engineering, Study on phosphorylated hollow silica / polysulfone hybrid membrane for the treatment of wastewater containing oil, £24000.
(vii) 2011-2014, EPSRC, EP/I010939/1, £664,440, FOCUS – Fundamentals of Optimised Capture Using Solids: circulating fluidised bed CO2 capture processes for coal-fired power plants based on amine-functionalised adsorbents.
(viii) 10/2011 - 9/2014, PhD studentship, Carnegie Trust for the Universities of Scotland, Transport of three phase flow in porous media for CO2 storage and enhanced oil recovery, £60,000.
(ix) 2010-2011 Research Grant from the Royal Society, £17,745,

URL: https://www.eng.ed.ac.uk/about/people/dr-xianfeng-fan

List of Publications

1.    C. Chao, X. Jin, L. Teng, A.A. Stokes, X. Fan, Bubble Dislodgment in a Capillary Network with Microscopic Multichannels and Multibifurcation Features, Langmuir, 2019, DOI: 10.1021/acs.langmuir.8b03323

2.    E Al-Zaidi, X Fan*, Liquid CO2 behaviour during water displacement in a sandstone core sample, Journal of Natural Gas Science and Engineering 62, 259-274, 2019

3.    C Chao, G Xu, X Fan*, Effect of surface tension, viscosity, pore geometry and pore contact angle on effective pore throat, Chemical Engineering Science, 197, 269-279, 2019

4.    E Al-Zaidi, K Edlmann, X Fan*, Gaseous CO2 behaviour during water displacement in a sandstone core sample, International Journal of Greenhouse Gas Control 80, 32-42, 2019

5.    C Chao, X Xu, SO Kwelle, X Fan*, Significance of gas-liquid interfaces for two-phase flows in micro-channels, Chemical Engineering Science 192, 114-125, 2018

6.    E Al-Zaidi, X Fan*, K Edlmann, Supercritical CO2 behaviour during water displacement in a sandstone core sample, International Journal of Greenhouse Gas Control 79, 200-211, 2018

7.    F Bougie, X Fan*, Microwave regeneration of monoethanolamine aqueous solutions used for CO2 capture, International Journal of Greenhouse Gas Control 79, 165-172, 2018

8.    L Liu, H Chen, E Shiko, X Fan, Y Zhou, G Zhang, X Luo, XE Hu, Low-cost DETA impregnation of acid-activated sepiolite for CO2 capture, Chemical Engineering Journal 353, 940-948, 2018

9.    E Al-Zaidi, J Nash, X Fan*, Effect of CO2 phase on its water displacements in a sandstone core sample, International Journal of Greenhouse Gas Control 71, 227-238, 2018

10.    E Al-Zaidi, X Fan*, Effect of aqueous electrolyte concentration and valency on contact angle on flat glass surfaces and inside capillary glass tubes, Colloids and Surfaces A: Physicochemical and Engineering Aspects 543, 1-8, 2018

11.    E Al-Zaidi, X Fan*, K Edlmann, The Effect of CO2 Phase on Oil Displacement in a Sandstone Core Sample, Fluids 3 (1), 23-, 2018

12.    Y. Guo*, H. Wu, X. Fan*, L. Zhoua, Q. Chen, Palladium composite membrane fabricated on rough porous alumina tube without intermediate layer for hydrogen separation, International Journal of Hydrogen Energy, 42, 9958–9965, 2017.

13.    Y. Guo, Y. Jin, H Wu, D. Li, X. Fan, Direct synthesis of propylene oxide using hydrogen peroxide in a membrane reactor, Chemical Papers, 71, 49-57, 2017

14.    S.J. McGurk, C.F. Martín, S. Brandani, M.B. Sweatman, X. Fan*, Microwave Swing Regeneration of Aqueous Monoethanolamine for Post-Combustion CO2 Capture, Applied Energy, 192, 126–133, 2017

15.    S. Farrukh, X. Fan, A. Hussain, A comparative CO2 adsorption analysis in pure and amine modified composite membranes. Polymer-Plastics Technology and Engineering, 56, 1158–1166, 2017

16.    C.F. Martín, M.B. Sweatman, S. Brandani, X. Fan*, Wet impregnation of a commercial low cost silica using DETA for a fast post-combustion CO2 capture process, Applied Energy, 183, 1705–1721, 2016.

17.    Dne. Nagy, D. Nagy, I.M Szilagyicd, X. Fan*, Effect of the morphology and phases of WO3 nanocrystals on their photocatalytic efficiency, RSC Adv. 6, 33743, 2016. 1 citation.

18.    D Nagy, T Firkala, X Fan†, I.M. Szilágyi, A study of the effect of the morphology on the photocatalytic activity of WO3,  Eur. Chem. Bull., 5, 40-42, 2016

19.    S. Hafeez, X. Fan†, A. Hussain, C.F. Martín, CO2 adsorption using TiO2 composite polymeric membranes: A kinetic study, Journal of Environmental Sciences, 35, 163-171, 2015. 2 citations.

20.    X. Li, X. Fan*, Effect of CO2 phase on contact angle in oil-wet and water-wet pores, International Journal of Greenhouse Gas Control, 36, 106-113, 2015. 8 citations.

21.    X. Li, H. Fan, X. Fan*, Effect of chemical structure of organics on pore wetting, Chemical Engineering Science, 137, 458-465, 2015. 1 citation

22.    S. Hafeez, X. Fan†, A. Hussain, A Kinetic Study of CO2 Adsorption in Cellulose Acetate Membranes, International Journal of Environmental Science and Development, 6, 755-759, 2015.

Christoforos G. Kokotos is an Assistant Professor of Organic Chemistry at the Department of Chemistry, National and Kapodistrian University of Athens, Greece, with undergraduate studies at the University of Athens, PhD studies at the University of Bristol, UK (Prof. Varinder Aggarwal) and post-doctoral studies at Princeton University, USA (Prof. David W. C. MacMillan). His research interests focus on the development of novel asymmetric organocatalytic methodologies, green and sustainable organocatalytic oxidations, Photocatalysis, their application in the synthesis of pharmaceuticals, compounds of biological importance and natural products and the study of the mechanisms of organic transformations employing modern techniques, like HRMS. He is co-author of 71 peer-reviewed papers, 4 book chapters, 2 patents, >40 presentations in conferences. He is the recipient of prestigious awards, like the Hildergard-Zervas Award, Academy of Athens (2016 and 2018), JSP fellowship for the Burgenstock Conference (2016), Young Investigators Workshop (3 times representing Greece, 2014, 2017 and 2018) and ACS Young Academic Investigators Award (2014, representing Europe).

Research Interest: Organic Chemistry, Food Chemistry, Green Chemistry

Grants: (1) Research Funding Scheme Post-doc, “PEPCAT-Novel Organocatalysts Based on Peptides and Amino Acids and their Application in Asymmetric Organic Transformations”, General Secretariat for Research and Development (2012-2015, 150.000 €).

(2) Organocatalysis – ORCA, Cost Action CM0905 funded by the intergovernmental framework for European Cooperation in Science and technology (2011-2014), Management Committee Substitute and co-Organizer of the third ORCA meeting in Athens, 2012. Action Chair: Prof. P. Pihko, University of Jyvskyl, Finland.

(3) Research Proposal Funding Scheme, John Latsis Foundation “PhotoOrganocatalysis: Development of new environmentally-friendly methods for the synthesis of compounds for the pharmaceutical and chemical industry” (2015, 12.000€).

(4) C-H Activation in Organic Synthesis – CHAOS, Cost Action CM15106 funded by the intergovernmental framework for European Cooperation in Science and technology (2016-2020), Management Committee Substitute. Action Chair: Prof. M. Schnurch, Technical University of Vienna, Austria.

(5) Fellowship for PhD programme, Ms Errika Voutyritsa, State Scholarships Foundation (IKY), 2016.

(6) Fellowship for PhD programme, Ms Ierasia Triandafillidi, Hellenic Foundation for Research and Innovation (ELIDEK), 2017.

(7) Fellowship for PhD programme, Mr Nikolaos Nikitas, State Scholarships Foundation, 2018.

(8) European Network on Pseudomyxoma Peritonei – PMP, Cost Action CA17101 funded by the intergovernmental framework for European Cooperation in Science and technology (2019-2023), Management Committee Member. Action Chair: Prof. Kjersti Flatmark, Oslo University Hospital, Norway.

(9) Chemobrionics, Cost Action CA17120 funded by the intergovernmental framework for European Cooperation in Science and technology (2019-2023), Management Committee Member. Action Chair: Prof. Julyan Cartwright, CSIC Granada, Spain.

(10) Fellowship for PhD programme, Ms Nikoleta Spiliopoulou, Hellenic Foundation for Research and Innovation (ELIDEK), 2019.

(11) Research Funding Scheme Teams of Young Investigators, “Green and Sustainable Organocatalysis: Novel Epoxidation reactions and their application in Chemical Industry”, General Secretariat for Research and Development (2019-2021, 50.000 €).

List of Publications:1.    “Photoorganocatalytic Synthesis of Acetals from Aldehydes” N. F. Nikitas, I. Triandafillidi and C. G. Kokotos*, Green Chem., 2019, 21, 669-674. (citations: 0) (Impact factor: 8.59)

2.    “Enantioselective Organocatalytic Enamine C-H Oxidation/Diels-Alder Reaction” Z. Dzambaski, D.-I. Tzaras, S. Lee, C. G. Kokotos and B. P. Bondzic*, Adv. Synth. Catal., 2019, 361, 1792-1797. (citations: 0) (Impact factor: 5.12)

3.    “Photocatalytic Atom Transfer Radical Addition to Olefins utilizing Novel Photocatalysts” E. Voutyritsa, I. Triandafillidi, N. V. Tzouras, N. F. Nikitas, E. K. Pefkianakis, G. C. Vougioukalakis and C. G. Kokotos*, Molecules, 2019, 24, 1644-1653. (citations: 0) (Impact factor: 3.09)

4.    “Photocatalytic Synthesis of γ-Lactones from Alkenes: High-Resolution Mass Spectrometry as a Tool to Study Photoredox Reactions” I. Triandafillidi, M. G. Kokotou and C. G. Kokotos*, Org. Lett., 2018, 20, 36-39. (citations: 8) (Impact factor: 6.49)

5.    “Organocatalytic Synthesis of Oxazolines and Dihydrooxazines from Allyl-Amides: Bypassing the Inherent Regioselectivity of the Cyclization” A. Theodorou, I. Triandafillidi and C. G. Kokotos*, Adv. Synth. Catal., 2018, 360, 951-957. (citations: 0) (Impact factor: 5.12)

6.    “Green Photo-Organocatalytic C−H Activation of Aldehydes: Selective Hydroacylation of Electron-Deficient Alkenes” G. N. Papadopoulos, E. Voutyritsa, N. Kaplaneris and C. G. Kokotos*, Chem. Eur. J., 2018, 24, 1726-1731. (citations: 2) (Impact factor: 5.16)

7.    “Expanding the Scope of Photocatalysis: Atom Transfer Radical Addition of Bromoacetonitrile to Aliphatic Olefins” E. Voutyritsa, I. Triandafillidi and C. G. Kokotos*, ChemCatChem, 2018, 10, 2466-2470. (citations: 1) (Impact factor: 4.67)

8.    “Photoorganocatalysis, Small Organic Molecules and Light in the Service of Organic Synthesis: the Awakening of a Sleeping Giant” I. K. Sideri, E. Voutyritsa and C. G. Kokotos*, Org. Biomol. Chem., 2018, 16, 4596-4614. Invited Review. (citations: 7) (Impact factor: 3.56)

9.    “Combining Οrganocatalysis with Photoorganocatalysis: Photocatalytic Hydroacylation of Asymmetric Organocatalytic Michael Addition Products” A. Schiza, N. Spiliopoulou,  A. Shahu and C. G. Kokotos*, New J. Chem., 2018, 42, 18844-18849. (citations: 7) (Impact factor: 3.28)

10.    “Proline Dipeptides Containing Fluorine Moieties as Organocatalysts for the Asymmetric Aldol Reaction” A. Ahmetlli, N. Spiliopoulou, A. Magi-Oikonomopoulou, D.-T. Gerokonstantis, P. Moutevelis-Minakakis* and C. G. Kokotos*, Tetrahedron, 2018, 74, 5987-5995. (citations: 0) (Impact factor: 2.65)

11.    “Green Organocatalytic Oxidative Methods using Activated Ketones” I. Triandafillidi, D. I. Tzaras, and C. G. Kokotos*, ChemCatChem, 2018, 10, 2521-2535. (citations: 1) (Impact factor: 4.67)

12.    “Combining Prolinamides with 2-Pyrrolidinone: Novel Organocatalysts for the Asymmetric Aldol Reaction” I. Vlasserou, M. Sfetsa, D. T. Gerokonstantis, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2018, 74, 2338-2349. (citations: 3) (Impact factor: 2.65)

13.    “Photoorganocatalytic Atom Transfer Radical Addition of Bromoacetonitrile to Aliphatic Olefins” E. Voutyritsa, N. F. Nikitas, M. K. Apostolopoulou, A. D. D. Gerogiannopoulou and C. G. Kokotos*, Synthesis, 2018, 50, 3395-3401. Invited Contribution for Special Issue: Photoredox Methods and their Strategic Applications in Synthesis (citations: 0) (Impact factor: 2.72).

14.    “Green Photoorganocatalytic Synthesis of Phenols from Arylboronic Acids” I. K. Sideri, E. Voutyritsa and C. G. Kokotos*, Synlett, 2018, 29, 1324-1328. Invited Contribution for Special Issue: 9th EuCheMS Organic Division Young Investigator Workshop (citations: 3) (Impact factor: 2.37)

15.    “Organocatalytic Synthesis of Lactones by the Oxidation of Alkenoic Acids” I. Triandafillidi, M. Raftopoulou, A. Savvidou, and C. G. Kokotos*, ChemCatChem, 2017, 9, 4120-4124. (citations: 3) (Impact factor: 4.67)

16.    “Photoorganocatalytic Synthesis of Lactones via a Selective C–H Activation–alkylation of Alcohols” N. Kaplaneris, A. Bisticha, G. N. Papadopoulos, D. Limnios and C. G. Kokotos*, Green Chem., 2017, 19, 4451-4456. (citations: 11) (Impact factor: 8.59)

17.    “Visible-Light-Mediated Catalytic Hydroacylation of Dialkyl Azodicarboxylates by Graphite Flakes” G. S. Koutoulogenis, M. G. Kokotou, E. Voutyritsa, D. Limnios, C. G. Kokotos*, Org Lett., 2017, 19, 1760-1763. (citations: 11) (Impact factor: 6.49)

18.    “Organocatalytic Oxidation of Substituted Anilines to Azoxybenzenes and Nitro Compounds: Mechanistic Studies Excluding the Involvement of a Dioxirane Intermediate” E. Voutyritsa, A. Theodorou, M. G. Kokotou and C. G. Kokotos*, Green Chem., 2017, 1291-1298. (citations: 14) (Impact factor: 8.59) 2017 Green Chemistry Hot

19.    “Green Organocatalytic Synthesis of Indolines and Pyrrolidines from Alkenes” A. Theodorou and C. G. Kokotos*, Adv. Synth. Catal., 2017, 359, 1577-1581. (citations: 9) (Impact factor: 5.12)

20.    “Green Organocatalytic Synthesis of Isoxazolines via a One-Pot Oxidation of Allyloximes” I. Triandafillidi and C. G. Kokotos*, Org. Lett., 2017, 19, 106-109. (citations: 17) (Impact factor: 6.49)

21.    “Photoinitiated Thiol-Ene “Click” Reaction: An Organocatalytic Alternative” D. Limnios and C. G. Kokotos*, Adv. Synth. Catal., 2017, 19, 1291-1298. (citations: 20) (Impact factor: 5.12)

22.    “Organocatalytic Synthesis of Polysubstituted Tetrahydrofurans from Alkenes” A. Theodorou and C. G. Kokotos*, Green Chem., 2017, 19, 670-674. (citations: 11) (Impact factor: 8.59)

23.    “Green Organocatalytic Dihydroxylation of Alkenes” A. Theodorou, I. Triandafillidi and C. G. Kokotos*, Eur. J. Org. Chem., 2017, 11, 1502-1509. (citations: 5) (Impact factor: 2.88)

24.    “Green Organocatalytic Synthesis of Dihydrobenzofurans by Oxidation-Cyclization of Allylphenols” I. Triandafillidi, I. K. Sideri, D. I. Tzaras, N. Spiliopoulou and C. G. Kokotos*, Synthesis, 2017, 49, 4254-4260. Invited Contribution for Special Issue: Modern Strategies in Cyclization Reactions (citations: 2) (Impact factor: 2.77).

25.    “Green Organocatalytic Oxidation of Sulfides to Sulfoxides and Sulfones” E. Voutyritsa, I. Triandafillidi and C. G. Kokotos*, Synthesis, 2017, 49, 917-924. Invited Contribution for Burgenstock Conference (citations: 13) (Impact factor: 2.77).

26.    “Enantioselective Organocatalytic Synthesis of 2-Oxopiperazines from Aldehydes: Identification of the Elusive Epoxy Lactone Intermediate” N. Kaplaneris, C. Spyropoulos, M. G. Kokotou and C. G. Kokotos*, Org. Lett., 2016, 18, 5800-5803. (citations: 5) (Impact factor: 6.49)

27.    “One-pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes” G. N. Papadopoulos and C. G. Kokotos*, J. Org. Chem., 2016, 81, 7023-7028. (citations: 17) (Impact factor: 4.81)

28.    “Photoorganocatalytic One-pot Synthesis of Hydroxamic Acids from Aldehydes” G. N. Papadopoulos and C. G. Kokotos*, Chem. Eur. J., 2016, 22, 6964-6967. (citations: 27) (Impact factor: 5.12)

29.    “Green Organocatalytic α-Hydroxylation of Ketones” E. Voutyritsa, A. Theodorou and C. G. Kokotos*, Org. Biomol. Chem., 2016, 14, 5708-5713. Invited Article for the Special Thematic issue “New Talent in Organic and Medicinal Chemistry”. (citations: 10) (Impact factor: 3.56)

30.    “(Thio)urea-mediated Synthesis of Functionalized Six-membered Rings with Multiple Chiral Centers” G. Koutoulogenis, N. Kaplaneris and C. G. Kokotos*, Beilstein J. Org. Chem., 2016, 12, 462-495. Invited Article for the Special issue “Multifunctional Organocatalysis”. (citations: 19) (Impact factor: 2.76)

31.    “4-Fluoro and 4-Hydroxy Pyrrolidine-thioxotetrahydropyrimidinones: Organocatalysts for Green Asymmetric Transformations in Brine” N. Kaplaneris, G. Koutoulogenis, M. Raftopoulou and C. G. Kokotos*, J. Org. Chem., 2015, 80, 5464-6473. (citations: 21) (Impact factor: 4.81)

32.    “tert-Butyl Esters of Peptides as Organocatalysts for the Asymmetric Aldol Reaction” A. Bisticha, I. Triandafillidi and C. G. Kokotos*, Tetrahedron: Asymmetry, 2015, 26, 102-108. (citations: 15) (Impact factor: 2.13)

33.    “One-pot Synthesis of O-Allylhydroxylamines through the Organocatalytic Oxidation of Tertiary Allylic Amines followed by a [2,3]-Meisenheimer Rearrangement” A. Theodorou, D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2015, 21, 5238-5241. (citations: 20) (Impact factor: 5.12)

34.    “tert-Butyl Ester or Benzylamide of the Dipeptide Pro-Gly as Organocatalysts for the Asymmetric Aldol Reaction” I. Triandafillidi, A. Bisticha, E. Voutyritsa, G. Galiatsatou and C. G. Kokotos*, Tetrahedron, 2015, 71, 932-940. (citations: 20) (Impact factor: 2.65)

35.    “Conjugating Proline Derivatives onto Multi-walled Carbon Nanotubes: Preparation, Characterization and Catalytic Activity in Water” D. D. Chronopoulos, C. G. Kokotos, M. Tsakos, N. Karousis, G. Kokotos and N. Tagmatarchis, Mat. Lett., 2015, 157, 212-214. (citations: 5) (Impact factor: 2.69)

36.    “Functionalized Multi-walled Carbon Nanotubes in an Aldol Reactions” D. D. Chronopoulos, C. G. Kokotos, N. Karousis, G. Kokotos* and N. Tagmatarchis*, Nanoscale, 2015, 7, 2750-2757. (citations: 8) (Impact factor: 7.23)

37.    “Organocatalytic Oxidation Reactions” D. Limnios and C. G. Kokotos*, Current Organocatalysis, 2015, 2, 171-190. (citations: 3) (Impact factor: -)

38.    “Fullerene-proline Hybrids: Synthesis, Characterization and Organocatalytic Properties in Aldol Reactions” D. D. Chronopoulos, M. Tsakos, N. Karousis, C. G. Kokotos* and N. Tagmatarchis*, Mat. Lett., 2014, 137, 343-346. (citations: 11) (Impact factor: 2.69)

39.    “Photoorganocatalytic Hydroacylation of Dialkyl Azodicarboxylates by utilizing Activated Ketones as Photocatalysts” G. N. Papadopoulos, D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2014, 20, 13811-13814. (citations: 24) (Impact factor: 5.12)

40.    “2,2,2-Trifluoroacetophenone: An Organocatalyst for an Environmentally Friendly Epoxidation of Alkenes” D. Limnios and C. G. Kokotos*, J. Org. Chem., 2014, 79, 4270-4276. (citations: 37). Feature Article, ACS Editors Choice Article, Top Read Article for the last 12 months, Highlighted at TCI catalogue for 2,2,2-trifluoroacetophenone. (Impact factor: 4.81)

41.    “One-pot Synthesis of Ureas from Boc-Protected Amines” C. Spyropoulos and C. G. Kokotos*, J. Org. Chem., 2014, 79, 4477-4483. (citations: 30) (Impact factor: 4.81)

42.    “2,2,2-Trifluoroacetophenone as an Organocatalyst for the Oxidation of Tertiary Amines and Azines to N-Oxides” D. Limnios and C. G. Kokotos*, Chem. Eur. J., 2014, 20, 559-563. (citations: 34) (Impact factor: 5.12)

43.    “tert-Butyl Esters of Tripeptides based on Pro-Phe as Organocatalysts for the Asymmetric Aldol Reaction in Aqueous or Organic Medium” A. Psarra, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2014, 70, 608-615. (citations: 29) (Impact factor: 2.65)

44.    “Primary and Secondary Amine-(thio)ureas and Squaramides and their Applications in Asymmetric Organocatalysis” M. Tsakos and C. G. Kokotos*, Tetrahedron, 2013, 69, 10199-10222. (citations: 91) (Impact factor: 2.65)

45.    “Organocatalytic Oxidation of Organosilanes to Silanols” D. Limnios and C. G. Kokotos*, ACS Catalysis, 2013, 3, 2239-2243. (citations: 33) (Impact factor: 11.38)

46.    “β-tert-Butyl Aspartate as an Organocatalyst for the Asymmetric α-Amination of α,α-Disubstituted Aldehydes” A. Theodorou, G. N. Papadopoulos and C. G. Kokotos*, Tetrahedron, 2013, 69, 5438-5443. (citations: 23) (Impact factor: 2.65)

47.    “An Asymmetric Michael Addition of α,α-Disubstituted Aldehydes to Maleimides leading to a One-pot Enantioselective Synthesis of Lactones Catalyzed by Amino Acids” C. G. Kokotos*, Org. Lett., 2013, 15, 2406-2409. (citations: 49) (Impact factor: 6.49)

48.    “Microwave-Assisted Organocatalytic Cross-Aldol Condensation of Aldehydes” D. Limnios and C. G. Kokotos*, RSC Adv., 2013, 3, 4496-4499. (citations: 16) (Impact factor: 2.94)

49.    “Organocatalytic Asymmetric Domino Michael-Henry Reaction for the Synthesis of Substituted Bicyclo[3.2.1]octan-2-ones” M. Tsakos, M. R. J. Elsegood and C. G. Kokotos*, Chem. Commun., 2013, 49, 2219-2221. (citations: 45) (Impact factor: 6.29)

50.    “Novel Prolinamide-Ureas as Organocatalysts for the Asymmetric Aldol Reaction” P. Revelou, C. G. Kokotos* and P. Moutevelis-Minakakis*, Tetrahedron, 2012, 68, 8732-8738. (citations: 28) (Impact factor: 2.65)

51.    “Pyrrolidine-thioxotetrahydropyrimidinone as an Efficient Organocatalyst for the Enantioselective Michael Addition of Cyclic Ketones to Nitrodienes” M. Tsakos. M. Trifonidou and C. G. Kokotos*, Tetrahedron, 2012, 68, 8630-8635. (citations: 13) (Impact factor: 2.65)

52.    “A Tripeptide-like Prolinamide-Thiourea as an Aldol Reaction Catalyst” S. Fotaras, C. G. Kokotos and G. Kokotos, Org. Biomol. Chem., 2012, 10, 5613-5619. (citations: 35) (Impact factor: 3.56) 

53.    “Primary Amine-Thioureas with Improved Catalytic Properties for “Difficult” Michael Reactions. Efficient Organocatalytic Syntheses of (S)-, (R)-Baclofen and (S)-Phenibut” M. Tsakos, C. G. Kokotos and G. Kokotos, Adv. Synth. Catal., 2012, 354, 740-746. (citations: 47) (Impact factor: 5.12)

54.    “Enantioselective Organocatalytic α-Alkylation of Ketones Utilising SN-1 Type Reaction of Alcohols” M. Trifonidou and C. G. Kokotos*, Eur. J. Org. Chem., 2012, 1563-1568. (citations: 33) (Impact factor: 2.88)

55.    “Construction of Tertiary Alcohols Bearing Perfluoroalkyl Chains Catalyzed by Prolinamide-Thioureas” C. G. Kokotos*, J. Org. Chem., 2012, 77, 1131-1135. (citations: 46) (Impact factor: 4.81)

56.    “Organocatalytic “Difficult” Michael Reaction of Ketones with Nitrodienes Utilising Primary Amine-Thioureas Based on di-tert-Butyl Esters of Aspartic Acid” M. Tsakos and C. G. Kokotos*, Eur. J. Org. Chem., 2012, 576-580. (citations: 24) (Impact factor: 2.88)

57.    “Novel Pyrrolidine-thiohydantoins/thioxotetrahydropyrimidinones as Highly Effective Catalysts for the Asymmetric Michael Addition” C. G. Kokotos, D. Limnios, D. Triggidou, M. Trifonidou and G. Kokotos, Org. Biom. Chem., 2011, 9, 3386-3395. (citations: 37) (Impact factor: 3.56) 

58.    “Prolinamides bearing Thiourea Groups as Catalysts for Asymmetric Aldol Reactions” S. Fotaras, C. G. Kokotos, E. Tsandi and G. Kokotos, Eur. J. Org. Chem., 2011, 1310-1317. (citations: 50) (Impact factor: 2.88)

59.    “Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-independent Phospholipase A2” G. Kokotos, Y.-H. Hsu, J. Burke, C. Baskakis, C. G. Kokotos, V. Magrioti and E. A. Dennis, J. Med. Chem., 2010, 53, 3602-3610. (citations: 53) (Impact factor: 6.26)

60.    “Interactions at the Bilayer Interface and Receptor Site Induced by the Novel Synthetic Pyrrolidinone Analog MMK3” C. Fotakis, S. Gega, E. Siapi, C. Potamitis, K. Viras, P. Moutevelis-Minakakis, C. G. Kokotos, S. Durdagi, S. Golic Grdadolnik, B. Sartori, M. Rappolt and T. Mavromoustakos, Biochim. Biophys. Acta Biomembranes, 2010, 1798, 422-432. (citations: 23) (Impact factor: 3.44) 

61.    “Bacillus subtilis Esterase (BS2) and its Double Mutant have Different Selectivity in the Removal of Carboxyl Protecting Groups” E. Barbayianni, C. G. Kokotos, S. Bartsch, C. Drakou, U. Bornscheuer and G. Kokotos, Adv. Synth. Catal., 2009, 351, 2325-2332. (citations: 10) (Impact factor: 5.12) 

62.    “Primary Amine-thioureas based on tert-Butyl Esters of Natural Amino Acids as Organocatalysts for the Michael Reaction” C. G. Kokotos and G. Kokotos, Adv. Synth. Catal., 2009, 351, 1355-1362. (citations: 71) (Impact factor: 5.12) 

63.    “Sulfonamides of Homoproline and Dipeptides as Organocatalysts for Michael and Aldol Reactions” E. Tsandi, C. G. Kokotos, S. Kousidou, V. Ragoussis and G. Kokotos, Tetrahedron, 2009, 65, 1444-1449. (citations: 50) (Impact factor: 2.65) 

64.    “Synthesis of Medicinally Interesting Polyfluoro Ketones via Perfluoroalkyl Lithium Reagents” C. G. Kokotos, C. Baskakis and G. Kokotos, J. Org. Chem., 2008, 73, 8623-8626. (citations: 24) (Impact factor: 4.81)

65.    “Sulfur Ylide Mediated Three-component Aziridination and Epoxidation Reactions using Vinyl Sulfonium Salts” C. G. Kokotos, E. M. McGarrigle and V. K. Aggarwal, Synlett, 2008, 2191-2195, highlighted in Synfacts, 2008, 11, 1142. (citations: 24) (Impact factor: 2.37)

66.    “Aminals as Substrates for Sulfur Ylides: A Synthesis of Functionalised Aziridines and N-Heterocycles” C. G. Kokotos and V. K. Aggarwal, Org. Lett., 2007, 9, 2099-2102. (citations: 39) (Impact factor: 6.49)

67.    “A Practical Synthesis of a [2.2.1] Bicyclic Chiral Sulfide for Asymmetric Transformations” V. K. Aggarwal, G. Fang, C. G. Kokotos, J. Richardson and M. G. Unthank, Tetrahedron, 2006, 62, 11297-11303. (citations: 26) (Impact factor: 2.65)  

68.    “Hemi-aminals as Substrates for Sulfur Ylides: Direct Asymmetric Syntheses of Functionalised Pyrrolidines and Piperidines” C. G. Kokotos and V. K. Aggarwal, Chem. Commun., 2006, 2156-2158. (citations: 42) (Impact factor: 6.29)   

69.    “Synthesis, Binding Studies, and in vivo Biological Evaluation of Novel non-Peptide Antihypertensive Analogues” T. Mavromoustakos, P. Moutevelis-Minakakis, C. G. Kokotos, P. Kontogianni, A. Politi, P. Zoumpoulakis, J. Findlay, A. Cox, A. Balmforth, A. Zoga and E. Iliodromitis, Bioorg. Med. Chem., 2006, 14, 4353-4360. (citations: 21) (Impact factor: 2.79)

70.    “Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal PGE2 Release” T. L. Yaksh, G. Kokotos, C. I. Svensson, D. Stephens, C. G. Kokotos, B. Fitzsimmons, D. Hadjipavlou-Litina, X. Y. Hua and E. A. Dennis, J. Pharmacol. Exp. Ther., 2006, 316, 466-475. (citations: 56) (Impact factor: 3.87)

71.    “Synthesis and Activity of 2-Oxoamides containing Long Chain β-Amino Acids” V. Constantinou-Kokotou, A. Peristeraki, C. G. Kokotos, D. A. Six and E. A. Dennis, J. Peptide Sci., 2005, 11, 431-435. (citations: 18) (Impact factor: 1.55)

My specific research interests are synthetic methodology development, total synthesis, medicinal chemistry, natural product isolation and derivatization, proteomics, drug discovery and development, translational oncology

Research Interest:     Organic chemistry, medicinal chemistry, natural products, translational oncology, proteomics.

Research Interest: Topics in chemical quality control in pharmacy practice; Application of different analytical techniques for the determination of pharmaceuticals in the presence of their degradation product(s) including; Different spectrophotometric methods such as colorimetry, derivative and derivative-ratio spectrophotometry. Different chromatographic methods such as TLC-densitometry, Preparative TLC, Two-dimensional TLC, GC and HPLC. Monitoring of the degradation profile of the pharmaceuticals and kinetic studies. Synthesis of the degradation product(s) of the selected drugs and structure elucidation.Chemometric methods, such as CLS, PCR and PLS.

2017-Postdoctoral researcher

Gaziosmanpasa University, Turkey Plant Research Lab of Chemistry, Faculty of Arts and Sciences

2011-2016 PhD (Research Assis-tant) Gaziosmanpasa University Molecular Biology and Genetics, Faculty of Arts and Sciences

2008- 2011 Master (Research Assis-tant) Gaziosmanpasa University Molecular Biology and Genetics, Faculty of Arts and Sciences

2003-2007 Under graduate Cumhuriyet Univer-sity Biology, Faculty of Arts and Sciences

Research Interest:  Algae cultivation, Plant biotechnology, Secondary metabolite production

Grants: 

1. Bioprocessingof microalgae for production and recovery of high-value metabolites;", Texas A&M University, 23.08.2015 -29.11.2015

2. Activity Controlled Isolation of Isolated Secondary Metabolites from Cladophora fracta (Tubitak 2017-2018).

3. Investigation of Pharmacological Secondary Metabolites in Some Cyanobacteria Members and Investigation of the Effects of Various Stress Conditions on the Production of these Metabolites (2016- 2018 Bap Turkey).

List of Publications: 

1. Tunay Karan, Ramazan Erenler Zekeriya Altuner, Mahfuz Elmastas. Molecular Identification and Norharmane Quantification of Cyanobacterium, Geitlerinema carotinosum. International Journal of Pharmacy& Pharmaceutical Research.June 2017,  Vol.:9, Issue:3, 67-73.

2. Tunay Karan, Ramazan Erenler. Screening of Norharmane from Seven Cyanobacteria by High performance Liquid Chromatography. Pharmacogn. Mag. 11.10.2017, Vol: 13, Issue: 51, 723-725.

3.Tunay Karan, Zekeriya Altuner, Ramazan Erenler. Growth and Metabolite Production of Chroococcus minutus Under Different Temperature and Light Conditions. Journal of New Results in Science, 6:1 47-52, 2017.

4. Tunay KARAN, Taner DAŞTAN, İnanç BARAL, Zekeriya ALTUNER.   Effects of Differential Time Applications on Some Cyanobacterial Norharman Production Rates.  Cumhuriyet Üniversitesi Fen Fakültesi Fen Bilimleri Dergisi (CFD), Cilt 37, No. 4 (2016) ISSN: 1300-1949.

5. Tunay KARAN, Ramazan ERENLER, Zekeriya ALTUNER. Isolation and Molecular Identification of Some Blue-Green Algae (Cyanobacteria) from Freshwater Sites in Tokat Province of Turkey. Turkish Journal of Agriculture - Food Science and Technology, 5(11): 1371-1378, 2017

6.Tunay KARAN, Saban Tekin, Ahmet Bursalı, Adem Keskin. Investigation of Tick-Borne Encephalitis Virus (TBEV) in Ixodid Ticks  Collected from Central Black Sea Region in Turkey. Journal of New Results in Science 4 (2014) 30-35

7.Sevgi Durna Dastan, Naci Degerli, Taner Dastan, Fazilet Yildiz, Yavuz Yildir, Yusuf Muhammed Durna, Dilek Atessahin  and Tunay Karan. Phenylthiocarbamide taste perception as a possible genetic association marker for nutritional habits and obesity tendency of people. Pak. J. Pharm. Sci., Vol.28, No.3(Suppl), May 2015, pp.1141-1150. 

8. Sevgi Durna Daştan, Taner Daştan, Serap Çetinkaya, Dilek Ateşşahin, Tünay Karan. Evaluation of In Vitro Anticancer Effect of Plantago major L. and Plantago lanceolata L. Leaf Extracts from Sivas. Cumhuriyet Üniv. Sağ. Bil. Enst. Derg. 2016 (1)1: 07-14

9. Tunay KARAN, İlyas Yıldız, Ali Aydın, ,Ramazn Erenler Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf.  Rec. Nat. Prod. 12:3 (2018) 273-283

10. Ramazan Erenler, Tuğba Adak, Tunay KARAN, Mahfuz Elmastaş,İlyas Yıldız, Hüseyin Akşit,Gülaçtı Topcu,Murat Aydın Sanda. CHEMICAL CONSTITUENTS ISOLATED FROM ORİGANUM SOLYMICUM WITH ANTIOXIDANT ACTIVITITES. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics (EPSTEM)  2017,Volume 1, Pages 139-145

11. Tünay KARAN, Mesut KOYUNCU, İskender PARMAKSIZ, Köksal PABUÇCU, Zekeriya ALTUNER. Siyanotoksinler ve Biyosentezlerinden Sorumlu Genlerin Düzenlenmesi. Gaziosmanpaşa Fen Bilimeri Enstitüsü Bilimsel Araştırma Dergisi 11 (2015) 54-69 .

12. KARAN TÜNAY,TEKIN SABAN, BURSALI AHMET.‘Crimean-Congo Hemorrhagic Fever Virus in Ixodid Ticks in Tokat Province of Turkey. Abstracts / Journal of Biotechnology 161S (2012) 19–48. 

13. Tunay KARAN, Saban Tekin, Adem Keskin, Ahmet Bursalı. Testing The Presence of Tick-Borne Encephalitis Virus in Ixodid Ticks (Acari: Ixodidae) From Tokat and Ordu Vicinity. In vivo International Journal of Experimental and Clinical Pathophysiology and Drug Research. 25:3 467-576 (2011).

14. Tunay KARAN, Omer KAYIR, Zekeriya ALTUNER, Ramazan ERENLER.Growth and norharmane production of Chroococcus minutus under various stress conditions.2018, 1, 10-15.

15.Tunay KARAN.  Metabolic profile and biological activities of Lavandula stoechas L. Cellular and Molecular Biology E-ISSN : 1165-158X / P-ISSN : 0145-5680.

16. Tunay Karan, Ramazan Erenler. Fatty acid constituents and anticancer activity of Cladophora fracta (OF Müller ex Vahl) Kützing. Tropical Journal of Pharmaceutical Research October 2018; 17 (10): 1977-1982.

17. Tunay Karan, Ali Aydin. Anticancer potential and cytotoxic effect of some freshwater cyanobacteria. Tropical Journal of Pharmaceutical Research November 2018; 17 (11): 2183-2188.

18.Evanthia Mantzouki, Tunay KARAN and et. al. Temperature Effects Explain Continental Scale Distribution of Cyanobacterial Toxins. Toxins 2018, 10, 156.

19.Evanthia Mantzouki, Tunay KARAN and et. al. A European Multi Lake Survey dataset of

environmental variables, phytoplankton pigments and cyanotoxins. Scıentıfıc Data 5:180226 DOI: 10.1038/sdata.2018.226.

20. Tunay Karan and Bilge Hilal Cadirci. Evaluatıon of antımıcrobıal and antıoxıdant actıvıty of lepıdıum draba l. World Journal of Pharmaceutical Research, Vol 7, Issue 13, 2018.

Research Interest: Nanomedicine, hydrogels, gene medicine, tissue engineering

Research Interest: Ischemic Stroke, Diabetic Foot, Anderson-Fabry Disease, Congestive Heart Failure.

Research Interest: Nanotechnology, Photodynamic Therapy, Sonodynamic Therapy, Anti-Cancer and Anti-Infectious Medicines, Functional Food and Food Safety.

Hamed received his PhD in mechanical engineering on a collaborative project between the University of Limerick, Imperial College London and Helmholtz-Zentrüm Berlin, titled "Effect of prior deformation on creep behaviour of AISI 316H austenitic stainless steels" funded by Science Foundation Ireland and EDF (formerly British Energy Ltd.).

He worked at the Irish Centre for Composites Research as lecturer in Finite Element Analysis and Aircraft Structures, and as a post-doctoral researcher on three consecutive industrial-oriented projects on composites materials, MAAXIMUS project funded through EU FP7 grant agreement nº213371 led by Airbus (www.maaximus.eu), Design of Optimised Composites for Impact Applications (OPTCOM) project funded by Enterprise Ireland (grant CF/2013/3012B), and the Science Foundation Ireland funded FALCOM project (www.falcom.ie) on a novel adhesively bonded joining technology.

Research Interest: 

•    Airworthiness

•    Composites

•    Computing, Simulation & Modelling

•    Manufacturing of Functional Materials

•    Aerospace Materials

•    Nanomaterials

•    Renewable Energy

•    Smart Materials

•    Structures and Materials

URL: https://www.cranfield.ac.uk/people/dr-hamed-yazdani-nezhad-14085695

List of Publications: 

1.    Deane, S, Avdelidis HP, Ibarra-Castanedo C, Zhang H, Yazdani Nezhad H, Williamson AA, Mackley T, Davis MJ, Maldague X & Tsourdos A (2019) Application of NDT thermographic imaging of aerospace structures, Infrared Physics and Technology, 97 (March) 456-466.
2.    Liu Y, Zhang X, Lemanski S, Yazdani Nezhad H & Ayre D (2019) Experimental and numerical study of process-induced defects and their effect on fatigue debonding in composite joints, International Journal of Fatigue, 125 (August) 47-57.
3.    Sirikham A, Zhao Y, Yazdani Nezhad H, Du W & Roy R (2019) Estimation of damage thickness in fiber-reinforced composites using pulsed thermography, IEEE Transactions on Industrial Informatics, 15 (1) Article No. TII-18-2286 445-453.
4.    Yazdani Nezhad H,Stratakis D, Ayre D, Addepalli S & Zhao Y (2018) Mechanical performance of composite bonded joints in the presence of localised process-induced zero-thickness defects, Procedia Manufacturing, 16 91-98.
5.    Lotfian S, Giraudmaillet C, Yoosefinejad A, Thakur VJ & Yazdani Nezhad H (2018) Electrospun piezoelectric polymer nanofiber layers for enabling in situ measurement in high-performance composite laminates, ACS Omega, 3 (8) 8891-8902.
6.    Mgbemena CO, Li D, Lin MF, Liddel PD, Katnam KB, Kumar VT & Yazdani Nezhad H (2018) Accelerated microwave curing of fibre-reinforced thermoset polymer composites for structural applications: A review of scientific challenges, Composites Part A: Applied Science and Manufacturing, 115 (December) 88-103.
7.    Yazdani Nezhad H & Thakur VJ (2018) Effect of morphological changes due to increasing carbon nanoparticles content on the quasi-static mechanical response of epoxy resin, Polymers, 10 (10) Article No. 1106.
8.    Liu Y, Lemanski S, Zhang X, Ayre D & Yazdani Nezhad H (2018) A finite element study of fatigue crack propagation in single lap bonded joint with process-induced disbond, International Journal of Adhesion and Adhesives, Early online.
9.    Yazdani Nezhad H, Egan B, Merwick F & McCarthy CT (2017) Bearing damage characteristics of fibre-reinforced countersunk composite bolted joints subjected to quasi-static shear loading, Composite Structures, 166 (April) 184-192.
10.    Bhanushali R, Ayre D & Yazdani Nezhad H (2017) Tensile response of adhesively bonded composite-to-composite single-lap joints in the presence of bond deficiency, Procedia CIRP, 59 139-143.
11.    Yazdani Nezhad H, Zhao Y, Liddel PD, Marchante VR & Roy R (2017) A novel process-linked assembly failure model for adhesively bonded composite structures, CIRP Annals - Manufacturing Technology, 66 (1) 29-32. Dataset/s: 10.17862/cranfield.rd.4681009
12.    Yazdani Nezhad H & O'Dowd N (2015) Creep relaxation in the presence of residual stress, Engineering Fracture Mechanics, 138 250-264.
13.    Zhou Y, Yazdani Nezhad H, Hou C, Wan X, McCarthy C & McCarthy M (2015) A three dimensional implicit finite element damage model and its application to single-lap multi-bolt composite joints with variable clearance, Composite Structures, 131 1060-1072.
14.    Yazdani Nezhad H, Merwick F, Frizzell R & McCarthy C (2014) Numerical analysis of low-velocity rigid-body impact response of composite panels, International Journal of Crashworthiness, 20 (1) 27-43.
15.    Zhou Y, Yazdani-Nezhad H, McCarthy M, Wan X & McCarthy C (2014) A study of intra-laminar damage in double-lap, multi-bolt, composite joints with variable clearance using continuum damage mechanics, Composite Structures, 116 441-452.
16.    Yazdani Nezhad H & O'Dowd NP (2012) Study of creep relaxation under combined mechanical and residual stresses, Engineering Fracture Mechanics, 93 132-152.